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Book Title: Treating and Preventing Adolescent Mental Health Disorders  > pp. [xxv]-[xxix]
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Introduction
At least one in five youth suffers from a current developmental, emotional, or behavioral problem (Burns et al., 1995; Institute of Medicine, 1989; Irwin, Burg, & Cart, 2002; U.S. Department of Health and Human Services, 1999; Zill & Schoenborn, 1990). The prevention and treatment of such difficulties in adolescence is one of the major public health problems facing the United States. To help adolescents achieve their full potential both as youths and as adults, it is important that we focus resources on this issue now. Helping adolescents reach their potential involves the identification, treatment, and prevention of mental disorders that interfere with the adolescent's development into a successful adult. However, getting rid of the disorder is not enough. We need also to instill positive values and behaviors that enable formerly troubled young people to flourish, contribute to society, and be happy and healthy.
Our goal with this book is to provide a comprehensive evaluation of what we know, and what we don't know, about adolescent mental health to create a road map for further scientific study and point the way toward needed changes in social policy. Our hope is that the current volume can advance the field through a state-of-the-art summary of empirical research on adolescent mental health, positive youth development, and the treatment and prevention of mental disorders in this age group.
In this introductory chapter, we set the context for our evaluation of adolescent mental health. We first address the question, “why focus on adolescence?” Following this, we provide an introduction to the specific mental disorders that are the main focus of this book and define some of the terms used throughout the book. We next give an overview of some of these special characteristics of the adolescent period so as to give the reader an understanding of the importance of this period of life to mental health. This includes a brief introduction to brain development during adolescence and an overview of genetic and environmental processes that are important at this stage of life. We then orient the reader to the history and structure of this volume and provide the rationale for the set of concluding chapters.
WHY FOCUS ON ADOLESCENCE?
Adolescence, which we define here broadly as ages 10 to 22, is a unique and distinct period in the development of human beings. The unique aspects of this developmental period have enormous implications not only for mental health and disorder among young people but for adults as well. Adolescence is a critical period of development characterized by significant changes in brain development, endocrinology, emotions, cognition, behavior, and interpersonal relationships. This period of life is a transitional period of development that is foundational but also noticeably malleable and plastic from a neurobiological, behavioral, and psychosocial perspective.
From a mental health perspective, adolescence is important because most of the major mental disorders begin not in childhood but during adolescence. After onset in adolescence, many chronic mental disorders carry over into adulthood, leading to ongoing significant mental health impairment during the adult years. This later influence of adolescence applies to not only the major mental disorders but also a range of health habits that influence adult behavior and may influence medical diseases in adulthood. Specifically, adolescent development and
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behaviors set the stage for adult behavior in terms of use of substances (both legal and illegal) and dietary habits and can have an impact on the development and outcome of medical illnesses, such as cardiovascular disease, diabetes, obesity, osteoporosis, and HIV/AIDS.
The past two decades of research have revealed that many mental disorders are relatively common in adolescence. Details of epidemiological studies of mental disorders in adolescents are presented in each of the disorder-focused chapters in this volume. Some of the more striking examples are the following:
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The lifetime prevalence rate of major depressive disorder in adolescence is estimated to be about 15%, but 20% to 30% of adolescents report clinically significant levels of depressive symptoms (Chapter 1).
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Over half of young people have used an illicit drug by the time they graduate from high school (Chapter 17).
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The 12-month prevalence estimates for anxiety disorders in adolescents range from 9% to 21% (Chapter 9).
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Suicide is the third leading cause of death among youth (Chapter 21).
What is especially alarming is that the prevalence of some of these disorders has been on the rise over each successive generation. Certain changes over time in the nature of adolescence, and the environments that adolescents find themselves in, may be responsible for these observed increases in the prevalence of psychopathology in adolescence. A major factor is that adolescence itself is now more extended. Puberty has been occurring progressively earlier, particularly in developed countries such as the United States (Parent et al., 2003). At the other end, full-time work and marriage now occur later in life. Thus, if adolescence is defined in terms of the onset of puberty, the total time spent in adolescence is now longer than in the past, and if its upper end is defined as the end of formal schooling, the total time is now much longer. Access to and availability of potentially harmful environments and substances have increased. For example, many types of abusable drugs can now be ordered through the mail via the Internet (For man, 2003; National Drug Intelligence Center, 2002). Compounding the potentially negative consequences of harmful environments is the increasing behavioral independence of adolescents in association with less parental or even adult influence.
There are many unanswered questions about the ways in which the interplay between biology and environment lead to the alarming numbers of adolescents we now see afflicted with mental illness and why this seems to have worsened in recent years. However, what is clear is the need to make adolescent mental health a major public health priority. A decade ago, early childhood moved into the spotlight and became a major health priority, but from the point of view of mental health, adolescence may be the more critical transitional period given its neurobiological and behavioral plasticity. It is, moreover, likely the optimal time for prevention and treatment of psychopathology, and for the promotion of mental health and positive emotional and behavioral functioning. By increasing our knowledge of the causes, treatment, and prevention of mental disorders that begin in adolescence, we will help reduce the suffering and impairments associated with these disorders and reduce overall health care utilization. Furthermore, progress in adolescent mental health could prevent mental disorders in adulthood that have onset in adolescence and modify the prevalence or course of medical illnesses in adulthood that are related in part to adolescent behaviors or mental disorders.
WHY THESE DISORDERS?
For the current volume, we have chosen to concentrate on mood disorders, anxiety disorders, eating disorders, suicide, substance use disorders, and schizophrenia. These disorders represent the major mental disorders or public health issues among adolescents, with the exception that conduct disorder and attention-deficit hyperactivity disorder, two important disorders of adolescence, are not represented in the current volume. This decision was made because these disorders have clearer roots in childhood and they were extensively covered in the parallel
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book, A Guide to Treatments That Work (Nathan & Gorman, 2002), which focused primarily on adults.
Mood Disorders
Although for many years depression was considered a problem that afflicted only adults, in the last 30 years there has been increasing recognition that this disorder can and does occur in children, particularly in adolescents. Fifty years ago, its mean age of onset was near 30, but now it is closer to 15. As mentioned previously and reviewed in the chapters on mood disorders, major depressive disorder is now seen as not uncommon in adolescents. When it occurs, it often has a severe impact on school performance and interpersonal relationships of afflicted youth. Since depression is a recurring disorder, its onset in puberty predicts an increase in the incidence of major depressive disorder. This constellation of facts about depression suggests that the adolescent years are key to understanding the etiology and course of depressive disorders.
Although bipolar disorder occurs at a markedly lower prevalence than that of major depressive disorder, it often has an onset during adolescence and can progress into an extremely disabling condition during adulthood. Moreover, bipolar disorder is associated with high rates of suicide in adolescence. Identification and treatment of major depression and bipolar disorder in adolescence may be the key to preventing the insidious progression of these illnesses and thereby reducing the burden of the illness on the individual and society.
Anxiety Disorders
Each of the specific anxiety disorders (generalized anxiety disorder; panic disorder; agoraphobia; obsessive-compulsive disorder; posttraumatic stress disorder; simple phobia; social anxiety disorder; separation anxiety disorder) seen in youth occurs with relatively low prevalence, but combined together these disorders are relatively common. As described in chapters on anxiety disorders, some disorders (separation anxiety and phobic disorders) are more common in early childhood and then become less common by adolescence, whereas other disorders (panic disorder and agoraphobia) show the opposite developmental profile, increasing in adolescence. These changes suggest that something especially relevant to the nature and course of anxiety disorders is happening during the adolescent years and may provide clues to the etiology and prevention of these disorders.
Eating Disorders
The two major eating disorders, anorexia nervosa and bulimia nervosa, typically have their onset around the beginning of puberty. Aspects of adolescence provide a fertile context for the development of eating disorders during these years. As discussed in the chapters on eating disorders, there is a marked increase in energy requirements required to support normal growth and development, with caloric requirements for girls increasing by almost 50% and for boys, by 80%. Moreover, dieting related to self-perceived weight status is now extremely common among adolescents, with two of every three female high school students trying actively to lose weight. Both of these eating disorders are of concern from a public health point of view. The mortality rate among individuals with anorexia nervosa is particularly a concern. For bulimia nervosa, only about half of those with the disorder can be expected to recover, with the rest displaying an ongoing significant impact on physical and psychosocial functioning.
Suicide
Suicide among young people has become an increasing concern over the past several decades. Although there has been a decrease in suicides among youth recently, the suicide rate among youth is now over double what it was 50 years ago. Possible reasons for this increase, as discussed in the chapters on youth suicide, include higher rates of depression and substance use, lower family cohesion, and higher availability of firearms (which are used in about 60% of sui
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cides). It may also be that increased awareness of suicide and documentation of suicides has contributed to an increase in recorded suicides over time. Although actual suicides are rare—about 8 per 100,000 among 15-to 19-year-olds—an alarming number of adolescents attempt suicide. Among U.S. high school students, almost 9% will have attempted a suicide in the past year. Despite the widely acknowledged importance of increased attention to the problem of youth suicide, the scientific evaluation of suicide prevention programs and risk factors associated with suicide is in its infancy. This area remains a high priority for the health of our nation.
Substance Use Disorders
Substance use is a ubiquitous problem among adolescents. Heroin, marijuana, cocaine, ec-stasy, methamphetamine, inhalants, as well as new so-called club drugs such as gamma-hydroxybutyrate, flunitrazepam, and ketamine, are all used and abused by youths. As detailed in the chapters on substance use disorders, educational and preventive programs have had some success, with use of substances among adolescents decreasing slightly in recent years. Unfortunately, there is historical evidence to suggest that as soon as one birth cohort of adolescents shows reduced drug use after learning about the dangers and consequences of a particular drug through either education or personal experience, the next cohort of children enters adolescence without such knowledge and is prone to experience the dangers of a particular drug on their own. Moreover, new drugs continue to appear, such as the newer club drugs, for which there are few scientific studies of the short-or long-term effects and little accumulated street knowledge of the consequences of use. The advent of these new drugs further contributes to the ongoing high levels of substance use among adolescents.
The largest substance use problem among adolescents is not illicit drugs but alcohol. Surveys have documented that 0.4% to 9.6% of adolescents meet diagnostic criteria for alcohol abuse, and another 0.6% to 4.3% meet criteria for de pendence (Chapter 17). The behavioral and psychosocial effects of alcohol and drug abuse and dependence are alarming, with school performance and social functioning deteriorating significantly. Addiction to illicit drugs such as heroin and cocaine can lead to a variety of illegal activities, including dealing, prostitution, and robbery as ways to pay for a drug habit. Excessive drinking among adolescents has been linked to high-risk sexual behaviors, date rape, assaults, homicides, and suicides.
Of equal or greater concern are the long-term effects of substance use on the developing brain of adolescents. While the general public largely still views addiction as a moral or character problem, the scientific community increasingly has moved toward a disease model of addiction, with particular focus on the brain. Evidence for genetic vulnerability to addiction and the neuronal basis for many of the clinical features of substance dependence, including craving, tolerance, and withdrawal, have raised questions about the lasting effects of chronic drug use. In addition, as reviewed in the next section in this chapter, the adolescent brain is developing. There is a key neural vulnerability during the adolescent period: although the brain's reward system is fully developed in adolescents, other areas of the brain involved in decision making and judgment are not yet fully developed (see Chapter 17). Thus, the adolescent brain is ripe for experiencing the rewarding effects of drugs but without the decision-making capacity and judgment that would allow weighing the consequences of drug use.
Schizophrenia
Finally, although schizophrenia is often viewed as an adult disorder, it was included in this volume because its onset is often in adolescence. The outcome of schizophrenia is often devastating, with long-term chronic impairment lasting from adolescence or early adulthood throughout life. Basic research with neuroimaging and other techniques have begun to map out the relationship between brain development and the occurrence of schizophrenia in both children and ad
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olescents. Thus, a focus on schizophrenia in adolescence can provide hope for a better understanding of the disorder, and early interventions at this stage of life can potentially lessen, if not prevent, some of the devastating effects of the disorder as it continues into adulthood.
WHAT IS ADOLESCENCE?
Adolescence is a distinct developmental period characterized by significant changes in hormones, brain and physical development, emotions, cognition, behavior, and interpersonal relationships. It has been defined as beginning with the onset of sexual maturation (puberty) and ending with the achievement of adult roles and responsibilities (Dahl, 2004). As mentioned previously, in terms of chronological age, the range for adolescence is broadly inclusive, roughly 10 to 22 years of age. For a number of reasons, this range is only a guide. First, there are wide individual differences in development. The onset of puberty, along with its associated hormonal and physical changes, occurs significantly earlier for some youth than for others. A second reason is that different facets of adolescent development are on a different time course. While hormonal changes occur at the beginning of adolescence, certain executive functions of the brain are not completely developed until the early 20s. Moreover, different developmental trajectories have been found for different cognitive and emotional processes (Rosso, Young, Femia & Yurgelun-Todd, 2004). A third reason for the difficulty in specifying an exact age range is evidence showing that, particularly in developed countries such as the United States, the onset of puberty is at an earlier average age than seen previously (Parent et al., 2003). At the other end, cultural changes, such as expanding enroll-ment in postgraduate education, have kept young people from assuming adult roles until well into their late 20s. Thus the typical age range of adolescence has been redefined over time, and there are differences in age range between cultures and countries. Regardless of the specific age range of adolescence, the nature of changes in the adolescent brain over time are crucial for understanding why this period of development is particularly important for mental health.
The Developing Brain
The brain undergoes changes throughout life, with intervals of modest change punctuated by periods of more rapid transformation (Spear, 2000). Periods of more dramatic change include not only prenatal and early postnatal eras but also adolescence (Spear, 2000). There are a number of specific changes in the brain during the adolescent years. These include synaptic changes, myelination (extensive maturation of myelin), changes in the relative volume and level of activity in different brain regions, and hormonal interactions with brain structures. Technological advances, particularly the development of functional magnetic brain imaging techniques, have contributed substantially to the recent increase in knowledge about these brain changes.
The primary synaptic change seen during adolescence is, counterintuitively, a major reduction in the number of synapses. Rakic, Bourgeois, and Goldman-Rakic (1994) estimate that up to 30,000 cortical synapses are lost every second during portions of the pubertal period in nonhuman primates, resulting in a decline of nearly 50% in the average number of synaptic contacts per neuron, compared with the number prior to puberty. There is a similar loss of synapses in the human brain between 7 and 16 years of age (Huttenlocher, 1979), but the scarcity of human postmortem tissue makes it difficult to provide a more detailed description of this phenomenon. Although the implications of the massive pruning remain speculative, it is likely that it reflects active restructuring of connections and the sculpting of more mature patterns, with a corresponding pruning of connections with very little activity. And we know, for example, that some forms of mental retardation are associated with unusually high density of synapses (Goldman-Rakic, Isseroff, Schwartz, & Bugbee, 1983).
The elimination of large amounts of synapses,
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doi:10.1093/9780195173642.003.0001
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