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Book Title: Treating and Preventing Adolescent Mental Health Disorders  > pp. [185]-[189]
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somatic, emotional, and behavioral aspects of his or her own personal anxious experience. These sessions also allow the child to begin to think about various ways to overcome his or her anxiety.
Education and Skill-Building
During initial sessions, the anxious child learns to distinguish between various bodily reactions to emotions as well as the somatic reactions that are specific to his or her anxiety. Coupled with this awareness, the child is taught relaxation exercises designed to help the child develop further awareness of and control over physiological and muscular reactions to anxiety (see King, Hamilton, & Ollendick, 1994). This segment may be especially beneficial for children whose worry is accompanied by more severe somatic symptoms (see also Eisen & Silverman, 1998). In this way, anxious children may develop an awareness of their physiological responses to anxiety and use this as an “early warning signal” to initiate relaxation procedures.
Next, children are taught how to identify and modify anxious cognition (their internal dialogue). Therapist and child then discuss such thoughts and the child is encouraged to ask himself or herself the various possibilities that may occur in a given situation. It is believed that helping children to challenge their distorted or unrealistic cognition will promote more constructive ways of thinking and less dysfunctional emotional and behavioral responses. For example, the “perfectionistic” nature of many anxious children can be challenged as these children become better able to examine, test out, and reduce their negative self-talk, modify unrealistic expectations, generate more realistic and less negative self-statements, and create a plan to cope with their concerns. Importantly, the idea here is not necessarily to fill the child with positive self-talk. Rather, the ameliorative power rests in the reduction of negative self-talk, or the “power of non-negative thinking” (Kendall, 1984). This phenomenon is supported by recent evidence indicating that changing children's anxiety-ridden and negative self-talk—but not positive self-talk—mediates the changes in anxiety that are associated with treatment-produced gains (Treadwell & Kendall, 1996). Children learn problem-solving skills that help them to devise a behavioral plan to cope with their anxiety. This includes learning to recognize the problem, brainstorming and generating alternatives to managing their anxiety, weighing the consequences of each possible alternative, and then choosing and following through with their plan (see D'Zurilla & Goldfried, 1971). The therapist serves as a model during each phase of problem solving by, for example, reminding the child that problems and challenges are part of life or by brainstorming ideas without judgment. With the acquisition of problem-solving skills, children develop confidence in their ability to handle anxiety-provoking situations as well as everyday challenges that arise. They learn to judge the effectiveness of their efforts and reward themselves for these efforts. They also learn to identify those things they liked about how they handled a situation and those things that they may want to do differently. Here, children are encouraged to reward both complete and partial successes. Children with anxiety may have exceedingly high standards for achievement and be unforgiving and critical of themselves if they fail to meet these standards. Therefore, it is important for the therapist to emphasize and encourage self-reward for effort and partial success.
Exposure Exercises
The second phase of treatment focuses on exposure exercises in which children practice the newly acquired skills. In these sessions, participant youth are prepared for and exposed to various situations that induce anxiety. They are first exposed to imaginary and low-anxiety situations and gradually are exposed to moderate-and then high-anxiety situations. Through imaginal and in vivo exposures, the therapist assists the child in preparing for the exposure by, for example, discussing aspects of the situation that are likely to be troubling, working through the steps of the plan, and rehearsing. The in vivo exposures are extremely important, as these situations provide the child real opportunities to practice. Thus, they should be tailored to address the spe
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cific worries (sources of anxious distress) of the child.
The therapist also facilitates children's postexperience processing of the exposures, helping them to evaluate their performances and think of a reward. In so doing, the therapist helps to frame the current exposure experience in terms of a pattern for future coping. When designing the graduated hierarchy of exposures, it is beneficial for the therapist and child to collaborate to create in vivo exposures that are meaningful and memorable for the child. Homework assignments are an important feature of this program. Throughout the treatment, children complete tasks in a personal notebook, which allow them to practice their steps and to use their skills outside of session. Rewards are provided upon completion of the assignments.
As the end of the time-limited treatment approaches (starting with 3 weeks left), the therapist and child begin to discuss how the child will create and produce a “commercial” about his or her experiences in the program to be presented and videotaped during the last session of the treatment. Children are encouraged to use their imagination and create a videotape, audiotape, or booklet describing their experiences to help in telling other children about strategies for coping with anxiety. This effort is designed to not only help children organize their experiences but also afford them the opportunity to “go public” with their newly acquired skills and recognize their accomplishments. The commercial also serves as a tangible reward that children can take home with them once the treatment is completed and, although it may not be described as such, it is an in vivo exposure task with emotional, social, creative, and organizational features.
Developmental Considerations
The treatment manuals that have been written and evaluated in research (e.g., Kendall, Chu, Pimentel, & Choudhury, 2000) were designed for children between the ages of 8 and 13 years. Also designed for this age range, The Coping Cat Workbook (Kendall, 2000a) contains exercises that parallel treatment sessions in an effort to facilitate the child's involvement in the program and the acquisition of skills. Although some manual-based treatments have acquired the reputation of being somewhat rigid, the therapist working with this program is allowed flexibility, as life can be “breathed” into the manual to better fit the needs and functioning of the child (Kendall, Chu, Gifford, Hayes, & Nauta, 1998). Although adaptations can be made when working with older children, younger children may not have yet developed the cognitive skills necessary to participate fully in or benefit maximally from this intervention and children with an IQ below 80 may not have the prerequisite skills. Additionally, with developmental considerations, it is important to be cognizant of possible age-related increases in physiological functioning, emotional vulnerability, social and peer pressures, and comorbid conditions, as well as any other changes that these children may be experiencing. Accordingly, a CBT therapist manual and a related workbook for teenagers (Kendall, 2000a) are also available.
PHARMACOTHERAPY
Progress in the neurobiology of anxiety has focused on (1) identifying the central nervous system (CNS) substrates of anxiety and (2) the effects of rearing and environment in the progression of anxiety states with reference to their somatic substrates (Pine & Grun, 1999) in an evolutionary context (Leckman & Mayes, 1998). Convergent evidence from both child studies of stress and trauma as well as primate rearing and deprivation studies suggests that the effects of stress in the genesis of anxiety disorder can be profound. Important substrates for this “stress-response system” include brainstem arousal centers, particularly the locus ceruleus, which provides noradrenergic input to brainstem and more rostral arousal mechanisms (McCracken, Walkup, & Koplewicz, 2002); the amygdala located in the anterior temporal lobe, which processes threat cues and safety signals, with particular emphasis on social threat (Bremner, Krystal, Charney, & Southwick, 1996); the septal–hippocampal system that mediates glucorticoid sensitive context-conditioning within
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the framework of learned experience; striatal and neoriatal structures, such as the caudate nucleus, which with their cortical targets comprise the circuitry that mediates habitual automatic behaviors, such as those seen in obsessive-compulsive disorder (OCD; Rosenberg & Hanna, 2000); the orbital-frontal cortex, which assigns complex negative affective valence to cognitive attributions (Graybiel & Rauch, 2000); paralimbic structures, such as the anterior cingulate gyrus, which play an important role in directed and selective attention to threatening stimuli (Davidson, Abercrombie, Nitschke, & Putnam, 1999); and the dorsolateral and ventromedial prefrontal cortex, which respond to and modulate subcortical input and output, generating adaptive responses or, in the case of disease states, maladaptive anxiety-maintaining behaviors (Davidson et al., 1999). From an integrationist point of view, extensive afferent and efferent connections between these brain regions process a wide variety of internal and external threat cues and safety signals, integrate current experience with previous experience, and generate affective and cognitively mediated approach and avoidance behaviors that are either appropriate or inappropriate to the individual's current context.
The understanding of the neurobiology of anxiety has been propelled by new pharmacologic agents that impact CNS receptors within the stress–response system (Heim, Owens, Plotsky, & Nemeroff, 1997). For example, the serotonin system is involved in generating and maintaining normal and pathological fear (Stein, Westenberg, & Liebowitz, 2002). Modulation of this system with a serotonin reuptake inhibitor provides an effective treatment for OCD (March, Biederman, et al., 1998) and may be useful for separation anxiety, panic, and social phobia (Research Units of Pediatric Psychopharmacology (RUPP) Anxiety Group, 2001). Other major neurotransmitter systems that appear to be involved in pathological anxiety include the GABAergic/glutamergic, noradrenergic, and dopaminergic systems, with recent evidence also suggesting important roles for the neuropeptides cholecystokinin, neuropeptide Y, and corticotropin-releasing hormone (CRH) (Sallee & March, 2001). These neurotransmitter systems appear to work in concert to provide homeostasis with respect to the phasic management of threat, and dysregulation in the information processes linked to these substrates may be linked to anxiety states in children and adolescents. They also appear to interface with Kagan's notion of “behavioral inhibition,” which as a stable temperamental characteristic appears to be an index of biological vulnerability that under certain circumstances (e.g., separation-stress exposure) can contribute to the generation of an anxiety disorder (Biederman, Rosenbaum, Chaloff, & Kagan, 1995).
Brain mechanisms of response to threat that are highly conserved in evolutionary terms and are exquisitely sensitive to learned experience provide the CNS substrate for the information processes that, when dysregulated, produce pathological anxiety, as well as for normal fears and worry. Pharmacotherapy presumably biases these processes directly by influencing the neurotransmitter milieu within which these hierarchically distributed neural networks operate.
COMBINED TREATMENT
In a biopsychosocial approach, combined treatment may be the rule rather than the exception (e.g., the treatment of juvenile rheumatoid arthritis with ibuprofen and physical therapy). In a perfectly evidence-based world, selecting an appropriate treatment for the anxious child or adolescent from among the many possible options would be reasonably straightforward. In the complex world of research and clinical practice, choices are rarely clear-cut. In this regard, the treatment of the anxious child can be thought of as being partially analogous to the treatment of juvenile-onset diabetes, with the caveat that the target organ, the brain in the case of mental disorders, requires psychosocial interventions of much greater complexity. The treatment of diabetes and anxiety disorder can both involve medication—insulin in diabetes and in anxiety, typically a serotonin reuptake inhibitor. Each also involves an evidence-based psychosocial intervention. In diabetes, the psychosocial treatment of choice is diet and exercise, and in anxiety, exposure-based CBT. Depending on the
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presence of risk and protective factors, not every participant has the same outcome. Bright youngsters from well-adjusted, two-parent families typically may do better with either diabetes or anxiety than those beset with tremendous psychosocial adversity and family hardship. Also, not everybody recovers completely even with the best of available treatment, so some interventions need to target coping with residual symptoms, such as diabetic foot care in diabetes and helping patients and their families cope skillfully with residual symptoms in anxiety disorders.
Psychosocial treatments may be combined with a medication for one of several reasons. First, in the acute treatment of the severely anxious child, two treatments may provide a greater “dose” and thus, may promise a better and perhaps speedier outcome. For example, patients with OCD may opt for a combined treatment even though CBT alone may offer equal benefit (March & Leonard, 1998). Second, comorbidity may require two treatments, since different targets may require varied treatments. For example, treating an 8-year-old who has attention-deficit hyperactivity disorder (ADHD) and separation anxiety disorder (SAD) with a psychostimulant and CBT is a reasonable treatment strategy. Third, in the face of partial response, an augmenting treatment can be added to the initial treatment to improve the outcome. A selective serotonic reuptake inhibitor (SSRI) can be added to CBT or CBT can be added to an SSRI. In an adjunctive treatment strategy, a second treatment can be added to a first one to positively impact one or more additional outcome domains. For example, an SSRI can be added to CBT to address comorbid depression.
As our understanding of both mental disorders in youth and adolescent development increases, treatment innovations inevitably will accrue, including knowledge about when and how to combine treatments (see Table 10.1). The good news is that the National Institute of Mental Health (NIMH)-funded comparative treatment trials that include a combination cell as well as CBT and medication monotherapy conditions are currently under way. Unfortunately, adolescent cases play too small a role and appear in too small a number in these ongoing trials to allow for specific examination of the effects of CBT, medication, and their combination on adolescents with anxiety disorders. The clear mandate is for similar programmatic research with adolescent cases. Before such work is undertaken, however, we offer a review of what is known to date. Because the state of knowledge varies by disorder, our review will consider each of the anxiety disorders separately (i.e., social phobia, generalized anxiety disorder, separation anxiety disorder, specific phobia, panic disorder, obsessive-compulsive disorder, and posttraumatic stress disorder). The information will be provided within the categories of (a) acute treatment, (b) maintenance treatment, and (c) management of partial response and nonresponse. In each category we very briefly summarize what is known about the treatment of adults and then provide more detailed coverage of treatments for youth. As noted above, there are very few studies of combined treatments of any kind in child or adolescent samples. Moreover, with few exceptions (e.g., Barlow, Gorman, Shear, & Woods, 2000), most of the combined-treatment studies in adults have not included a CBT plus pill placebo condition, which leaves an important mechanism question essentially unanswered by the extant literature.
ACUTE TREATMENT
Social Anxiety Disorder
Treatment of Social Anxiety Disorder in Adults
With respect to psychosocial interventions, behavioral, cognitive, and combined cognitive-behavioral interventions have each been found to be efficacious in the acute treatment of social phobia in adults, delivered either in groups or individually. Direct comparisons of behavioral and cognitive-behavioral treatments have been mixed, and it is unclear as yet whether there is a strong advantage for one over the other. As with pharmacotherapy, residual impairment remains an issue (for a comprehensive review see Hambrick, Turk, Heimberg, Schneier, & Liebowitz, 2003).
A variety of medications have been found use
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doi:10.1093/9780195173642.003.0011
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